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Publication Title | INDO GLOBAL JOURNAL OF PHARMACEUTICAL SCIENCES

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Indo Global Journal of Pharmaceutical Sciences, 2011; 1(4): 328-353

INDO GLOBAL JOURNAL OF PHARMACEUTICAL SCIENCES

ISSN 2249- 1023

Advances in Formulation of Orally Disintegrating Dosage Forms: A Review Article

Rakesh Kumar Bhasin*1, Nirika Bhasin2, Pradip Kumar Ghosha

1 Research & Development Lab, Dr. Reddy’s Limited, Hydedrabad, India 2 Guru Nanak Dev University, Amritsar, Punjab, India

Address for Correspondance: bhasinrakesh@hotmail.com

ABSTRACT: Oral disintegrating tablets are solid dosage form containing medicinal substances which disintegrates rapidly, usually within a matter of seconds, when placed upon the tongue The products are designed to disintegrate or dissolve rapidly on

contact with saliva, thus eliminating the need for chewing the tablet, swallowing an intact tablet, or taking the tablet with water. ODT is general form of nomenclature for tablets that disintegrate rapidly or instantly in the oral cavity. Other alias are Quick Dissolve, Rapid Dissolve, Rapid Disintegrating, Fast Disintegrating, Fast Melt, Flash Melt and Mouth Dispersing. © 2011 IGJPS. All rights reserved.

KEYWORDS: Orally Disintegrating Tablets; ODT Technology; Taste Masking.

INTRODUCTION

All fast disintegrating tablets approved by USFDA are classified as Orally disintegrating tablets. European Pharmacopoeia1 adopted the term Orodispersible Tablets for tablets that dispersed or disintegrate in less than 3 minutes in the mouth before swallowing. Such a tablet disintegrates into smaller granules or gel like structure, allowing easily swallowing by patients. As per recent USFDA guideline2 on Orally Disintegrating Tablets (Dec’2008), disintegration time of ODT should have an invitro disintegration time of approximate 30 seconds or less, when based on United State Pharmacopeia (USP) disintegration test method or alternative. Secondly tablet weight should not exceed 500 mg. as larger tablets may have an effect on patient safety and compliance.

WHO REQUIRES OR PREFER ORALLY DISINTEGRATING TABLETS:

This mode of administration was initially expected to be beneficial to pediatric and geriatric patients, to people with conditions related to impaired swallowing, and for treatment of patients when compliance may be difficult (e.g., for psychiatric disorders).

1. Around 35% of general population as well as additional 30-40% of elderly institutionalized patients and 18-22% of all persons in long term facilities have difficulty in swallowing in conditions such as Parkinson, Migraine, Epilepsy and

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